COMFORT Project
Clinical outcomes and microbiota in functional constipation: Randomized, double-blind, placebo-controlled clinical trial with probiotics
Clinical Outcomes and Microbiota in Functional C onstipation : Double-Blind, R andomized, Placebo-Controlled Probiotic Trial
Functional constipation is a common condition that affects the quality of life of many people, especially adult women. Evidence suggests that alterations in the intestinal microbiota may be involved in its pathophysiology, which raises interest in interventions with probiotics as a non-pharmacological therapeutic approach.
The COMFORT (Clinical Outcomes and Microbiota in Functional Constipation: Randomized, Double-Blind, Placebo-Controlled Probiotic Trial) study aims to evaluate the effects of a mixture of probiotic strains in improving the symptoms of functional constipation and modulating the intestinal microbiota.
In this study, women with a clinical diagnosis of functional constipation, according to the Rome IV criteria, undergo a four-week intervention with probiotics or placebo. During the study, aspects such as bowel habits, food intake, physical activity, body composition and fecal microbiota profile are monitored.
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